Drug metabolism | DATOSPDF

Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor

Metabolism / Evaluation / Pharmacokinetics / Drug metabolism / Mitochondria / Dogs / Cell line / Transport / Humans / Permeability / Mice / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Bioavailability / Clearance / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding / Dogs / Cell line / Transport / Humans / Permeability / Mice / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Bioavailability / Clearance / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Drug metabolism / Clinical Pharmacology / Cytochrome P450 Enzymes / PPARs

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Copper (II) Complexes of [1,2,4]Triazolo [1,5-a]Pyrimidine Derivatives as Potential Anti-Parasitic Agents

Drug metabolism / Macrophages / Leishmania / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells

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Human cytochromes P450

Drug metabolism / Biological Sciences / Metabolic Bone Disease / Fatty Acid / Genetic Polymorphism

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N-Acetyltransferase Polymorphism Among Northern Sudanese

Genetics / Geography / Polymorphism / Drug metabolism / Adolescent / Low Frequency / Sudan / Human Biology / Humans / Child / Haplotypes / Female / Male / Polymerase Chain Reaction / Phenotype / Enzyme / Arylamine N-acetyltransferase / Middle Aged / Genotype / Adult / Single Nucleotide Polymorphism / Adverse Drug Reaction / Molecular Computers / Drug Toxicity / Computational Method / Allele Frequency / Low Frequency / Sudan / Human Biology / Humans / Child / Haplotypes / Female / Male / Polymerase Chain Reaction / Phenotype / Enzyme / Arylamine N-acetyltransferase / Middle Aged / Genotype / Adult / Single Nucleotide Polymorphism / Adverse Drug Reaction / Molecular Computers / Drug Toxicity / Computational Method / Allele Frequency

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Microbial metalloproteomes are largely uncharacterized

Biochemistry / Chromatography / Proteomics / Drug metabolism / Cell Biology / Chemical Biology / Multidisciplinary / Nature / Protein Stability / Copper / Escherichia coli / Electron Transfer / Zinc / Iron / Tandem Mass Spectrometry / Nickel / Inductively Coupled Plasma Mass Spectrometry / High Performance Liquid Chromatography / Metalloproteins / Metals / Liquid Chromatography / Very high throughput / Biological Process / Metal ion / Genome sequence / Proteome / Microbial Growth / Chemical Biology / Multidisciplinary / Nature / Protein Stability / Copper / Escherichia coli / Electron Transfer / Zinc / Iron / Tandem Mass Spectrometry / Nickel / Inductively Coupled Plasma Mass Spectrometry / High Performance Liquid Chromatography / Metalloproteins / Metals / Liquid Chromatography / Very high throughput / Biological Process / Metal ion / Genome sequence / Proteome / Microbial Growth

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Neoral pharmacokinetics in Latino and Caucasian pediatric renal transplant recipients

Kidney transplantation / Drug metabolism / Adolescent / Humans / Child / African American / Female / Male / Cyclosporine / Pediatric Nephrology / Pediatric / European Continental Ancestry Group / Body Weight / Area Under the Curve / Ethnic Difference / Age Groups / African American / Female / Male / Cyclosporine / Pediatric Nephrology / Pediatric / European Continental Ancestry Group / Body Weight / Area Under the Curve / Ethnic Difference / Age Groups

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Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor

Drug metabolism / Dogs / Cell line / Humans / Mice / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding

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Copper (II) Complexes of [1,2,4]Triazolo [1,5-a]Pyrimidine Derivatives as Potential Anti-Parasitic Agents

Drug metabolism / Macrophages / Leishmania / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells

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CYP2A6 genetic variation and potential consequences

Genetics / Tobacco / Drug metabolism / Enzyme Inhibitors / Lung Cancer / Humans / Smoking / Nicotine / Gene Duplication / Enzyme / Neoplasms / Genetic Polymorphism / Genetic variation / Enzyme activity / Humans / Smoking / Nicotine / Gene Duplication / Enzyme / Neoplasms / Genetic Polymorphism / Genetic variation / Enzyme activity

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Human cytochromes P450

Drug metabolism / Biological Sciences / Metabolic Bone Disease / Fatty Acid / Genetic Polymorphism

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Microbial metalloproteomes are largely uncharacterized

Biochemistry / Chromatography / Proteomics / Drug metabolism / Cell Biology / Chemical Biology / Multidisciplinary / Nature / Protein Stability / Copper / Escherichia coli / Electron Transfer / Zinc / Iron / Tandem Mass Spectrometry / Nickel / Inductively Coupled Plasma Mass Spectrometry / High Performance Liquid Chromatography / Metalloproteins / Metals / Liquid Chromatography / Very high throughput / Biological Process / Metal ion / Genome sequence / Proteome / Chemical Biology / Multidisciplinary / Nature / Protein Stability / Copper / Escherichia coli / Electron Transfer / Zinc / Iron / Tandem Mass Spectrometry / Nickel / Inductively Coupled Plasma Mass Spectrometry / High Performance Liquid Chromatography / Metalloproteins / Metals / Liquid Chromatography / Very high throughput / Biological Process / Metal ion / Genome sequence / Proteome

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Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element

Gene regulation / Drug metabolism / Antioxidants / Humans / Liver / Curcumin / Glutathione / Detoxification / Plasmids / Enzyme / DNA binding proteins / Response Elements / ENVIRONMENTAL SCIENCE AND MANAGEMENT / Curcumin / Glutathione / Detoxification / Plasmids / Enzyme / DNA binding proteins / Response Elements / ENVIRONMENTAL SCIENCE AND MANAGEMENT

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Copper (II) Complexes of [1,2,4]Triazolo [1,5-a]Pyrimidine Derivatives as Potential Anti-Parasitic Agents

Drug metabolism / Macrophages / Leishmania / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells / Energy Metabolism / Cercopithecus aethiops / Copper / Mice / Animals / Drug Design / Trypanosoma Cruzi / Triazoles / NAD / Organometallic Compounds / Vero cells

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